Efek Ekstrak Daun Kemangi (Ocimum Basilicum) Terhadap Kadar LDL Tikus (Rattus Norvegicus) Model Aterosklerosis

Gita Kencana; Hirowati Ali; Noverial Noverial; Husnil Kadri; Liganda Endo Mahata; Dian Pertiwi

doi:10.31004/innovative.v5i3.19552

Authors

Gita Kencana Universitas Andalas
Hirowati Ali Universitas Andalas
Noverial Noverial Universitas Andalas
Husnil Kadri Universitas Andalas
Liganda Endo Mahata Universitas Andalas
Dian Pertiwi Universitas Andalas

DOI:

https://doi.org/10.31004/innovative.v5i3.19552

Keywords:

Aterosklerosis, Ekstrak Daun Kemangi, LDL, Ocimum Basilicum

Abstract

Penelitian ini bertujuan untuk mengetahui efek ekstrak daun kemangi (Ocimum basilicum) terhadap kadar LDL pada tikus (Rattus Norvegicus) model aterosklerosis. Desain yang digunakan adalah post-test only control group design dengan 30 ekor tikus jantan yang dibagi menjadi lima kelompok: kontrol negatif (K-), kontrol positif (K+), kontrol statin (KS), perlakuan I (P1; 100 mg/kgBB ekstrak daun kemangi), dan perlakuan II (P2; 200 mg/kgBB). Induksi aterosklerosis dilakukan melalui ligasi parsial arteri karotis dan pemberian diet tinggi lemak selama 7 hari. Pemberian simvastatin dan ekstrak kemangi dilakukan secara oral selama 7 hari. Kadar LDL diukur menggunakan metode CHOD-PAP dengan alat Microlab 300. Hasil analisis statistik menunjukkan perbedaan bermakna kadar LDL antara kelompok K-, KS, dan P2 dibandingkan dengan kelompok K+ (p<0,05). Rerata kadar LDL tertinggi ditemukan pada kelompok K+ (64,56 mg/dL) dan terendah pada kelompok KS (31,62 mg/dL). Dapat disimpulkan bahwa ekstrak daun kemangi, khususnya dosis 200 mg/kgBB, berpotensi menurunkan kadar LDL pada tikus model aterosklerosis.

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