Clinical Approach to Recurrent Hemoptysis Due to Pulmonary Mycosis: A Case Study of Aspergillus Fumigatus and Candida Albicans Infections
DOI:
https://doi.org/10.31004/innovative.v5i4.20659Keywords:
Recurrent Hemoptysis, Pulmonary Mycosis, Aspergillus FumigatusAbstract
Recurrent hemoptysis caused by pulmonary mycosis from Aspergillus fumigatus and Candida albicans infection presents a complex clinical challenge, particularly in patients with a history of pulmonary tuberculosis. This case study examines clinical characteristics, radiological findings, microbiological results, and responses to antifungal therapy, bronchial artery embolization, and lobectomy. The findings indicate that a comprehensive diagnostic and therapeutic approach effectively controls hemoptysis and improves patient outcomes despite risks of complications such as anemia and secondary infections. The study highlights the importance of integrated management and long-term monitoring to enhance clinical outcomes and reduce hemoptysis recurrence in pulmonary mycosis.
References
Agarwal, R. (2009). Allergic bronchopulmonary aspergillosis. Chest, 135(3), 805–826.
Aldiani, A., & Alatas, M. F. (2023). Pathophysiology of Haemoptysis in Lung Disease. Jurnal Respirologi Indonesia, 43(1), 58–65. https://doi.org/10.36497/jri.v43i1.441
Amiruddin, & Pohan, I. T. S. (2024). Hemoptisis Rekuren Akibat Mikosis Pulmonal (Aspergillus Fumigatus Dan Candida Albicans ): Sebuah Laporan Kasus. Jurnal Kedokteran Ibnu Nafis, 13(2), 74–84. https://doi.org/10.30743/jkin.v13i2.646
Assyakurrohim, D., Ikhram, D., Sirodj, R. A., & Afgani, M. W. (2023). Metode studi kasus dalam penelitian kualitatif. Jurnal Pendidikan Sains Dan Komputer, 3(01), 1–9.
Briard, B., Mislin, G. L. A., Latgé, J.-P., & Beauvais, A. (2019). Interactions between Aspergillus fumigatus and pulmonary bacteria: current state of the field, new data, and future perspective. Journal of Fungi, 5(2), 48.
Chu, C., Woo, P. C. Y., Chong, K. T. K., Leung, W., Chan, V. L., & Yuen, K. (2004). RETRACTED: Association of Presence of Aspergillus Antibodies with Hemoptysis in Patients with Old Tuberculosis or Bronchiectasis but No Radiologically Visible Mycetoma. Journal of Clinical Microbiology, 42(2), 665–669.
Fadhilah, Yani Sodiqah, Ali Polanunu, N. F., Wiriansya, E. P., Syamsu, R. F., Hasan, H., & Rumlawan, S. M. (2022). Deteksi Jamur Pada Sampel Sputum Penderita Tuberkulosis Paru. Fakumi Medical Journal: Jurnal Mahasiswa Kedokteran, 2(3), 207–215. https://doi.org/10.33096/fmj.v2i3.156
Ittrich, H., Bockhorn, M., Klose, H., & Simon, M. (2017). The diagnosis and treatment of hemoptysis. Deutsches Ärzteblatt International, 114(21), 371.
Kim, T. H., Koo, H. J., Lim, C.-M., Hong, S.-B., Huh, J. W., Jo, K. W., Shim, T. S., Kim, W. S., & Koh, Y. (2019). Risk factors of severe hemoptysis in patients with fungus ball. Journal of Thoracic Disease, 11(10), 4249.
Maloho, R. F., & Solikah, M. P. (2023). HUBUNGAN JAMUR Candida albicans dan Aspergillus fumigatus TERHADAP PASIEN TUBERKULOSIS PARU DI BALAI LABORATORIUM KESEHATAN DAERAH (BLKD) PROVINSI SULAWESI UTARA. Jurnal Analis Laboratorium Medik, 8(2), 108–116.
Mamudi, C. O. (2023). Diagnosis dan Tata Laksana Infeksi Paru akibat Jamur. Jurnal Kedokteran Meditek, 29(3), 327–333. https://doi.org/10.36452/jkdoktmeditek.v29i3.2845
Mora-Soize, C., Carsin-Vu, A., Mac Caby, G., Belkessa, N., Marcus, C., & Soize, S. (2022). Recurrent massive hemoptysis from distal pulmonary pseudoaneurysms complicating invasive aspergillosis in a teenager. Radiology Case Reports, 17(10), 3897–3902.
O’Gurek, D., & Choi, H. Y. J. (2022). Hemoptysis: evaluation and management. American Family Physician, 105(2), 144–151.
Önür, S. T., Altin, S., AKYIL, F. T., Kara, K., Sökücü, S. N., Özdemir, C., Özgül, M. A., Metin, M., Cansever, L., & Ölçmen, A. (2022). Management of recurrent hemoptysis: a single-center experience. Turkish Journal of Medical Sciences, 52(6), 1872–1880.
Palmieri, F., Koutsokera, A., Bernasconi, E., Junier, P., von Garnier, C., & Ubags, N. (2022). Recent advances in fungal infections: From lung ecology to therapeutic strategies with a focus on Aspergillus spp. Frontiers in Medicine, 9, 832510.
Peeva, M. (2022). Approach to Hemoptysis. McGill Journal of Medicine, 20(2).
Radchenko, C., Alraiyes, A. H., & Shojaee, S. (2017). A systematic approach to the management of massive hemoptysis. Journal of Thoracic Disease, 9(Suppl 10), S1069.
Reihill, J. A., Moore, J. E., Elborn, J. S., & Ennis, M. (2011). Effect of Aspergillus fumigatus and Candida albicans on pro-inflammatory response in cystic fibrosis epithelium. Journal of Cystic Fibrosis, 10(6), 401–406.
Sartika, S. D. (2022). Predisposisi, Patogenesis, dan Tatalaksana Pneumonia Fungal. Jurnal Sainsmat, XI, 2, 114–123.
Subay, S., & Yudhawati, R. (2023). Hemoptysis recurrence in an Indonesian female with pulmonary aspergilloma: A case report. International Journal of Surgery Open, 61, 100712.
Toh, T. W., Goh, J. H. F., Lie, S. A., Leong, C. K. L., & Hwang, N. C. (2024). Clinical approach to massive hemoptysis: Perioperative focus on causes and management. Journal of Cardiothoracic and Vascular Anesthesia, 38(10), 2412–2425.
Wardhana, D. E. A. (2012). A patient with allergic bronchopulmonary mycosis caused by Aspergillus fumigatus and Candida albicans. Acta Med Indones, 44, 317–323.
Willim, H. A., Munthe, E. L., & Mujono, W. (2023). Pulmonary aspergilloma presenting with recurrent hemoptysis in a patient with previously treated pulmonary tuberculosis: a case report from a rural hospital in Ketapang Regency. Journal of Indonesia Vascular Access, 3(2), 23–28. https://doi.org/10.51559/jinava.v3i2.44
Ye, J., Li, Y., Hao, J., Song, M., Guo, Y., Gao, W., Zheng, C., Huang, Y., Feng, Z., & Zhang, L. (2023). Rare occurrence of pulmonary coinfection involving Aspergillus fumigatus and Nocardia cyriacigeorgica in immunocompetent patients based on NGS: A case report and literature review. Medicine, 102(51), e36692.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Amiruddin Amiruddin

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.







